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Yet another consideration when starting on GLP-1s is the possibility of weight regain after stopping the medication

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The mechanistic case for combining AOD-9604 with GLP-1 therapy The case for combining AOD-9604 with semaglutide or tirzepatide does not rest on randomized controlled trial evidence, because that evidence does not exist

Int J Biol Sci 15(8):15711581 Abderrazak A, Syrovets T, Couchie D, El Hadri K, Friguet B, Simmet T, Elsevier B.V

The type 2 IGF receptor (IGF-2R / cation-independent mannose-6-phosphate receptor) does not signal in the classical sense but acts as a clearance sink for IGF-2 and, to a lesser extent, participates in ligand disposal